Definition
Lentiviruses are retroviruses capable of delivering large therapeutic payloads (up to ~10kb) into the host genome, making them ideal for long-term gene expression in dividing and non-dividing cells alike.
Clinical Value
Lentiviral vectors are widely used in gene therapy and gene editing, especially in CAR-T and stem cell-based therapies, due to their stable integration and high transduction efficiency.
OranssiBio Advantages
- 01
Fully GMP-compliant production platform for clinical and commercial use - 02
Serum-free suspension culture system with scalable capacity up to 200L, compatible with VSVG and BaEV pseudotypes - 03
Closed, automated manufacturing processes to enhance efficiency and batch consistency - 04
Integrated services from development to GMP production and quality release
Service Highlights
Efficient and scalable process development
Full-range analytical testing to support quality and regulatory compliance
Flexible batch sizes to meet different project stages
Deep expertise in viral vector production and regulatory documentation
Key Specifications
| Technical Specifications | Technical Parameters |
|---|---|
| Scale | 2L–200L |
| Pseudotypes | VSVG, BaEV |
| Purification | Chromatography, ultrafiltration |
| QC Methods | Titer, purity, residual DNA, etc. |
