Definition
Exosomes are nanoscale extracellular vesicles (30–150 nm in diameter) naturally secreted by cells. They carry various bioactive molecules such as proteins, mRNA, miRNA, and lipids, and play key roles in intercellular communication, immune modulation, and disease progression.
Clinical Value
Due to their natural origin, excellent biocompatibility, low immunogenicity, and ability to cross biological barriers, exosomes are widely studied as novel delivery vehicles, diagnostic biomarkers, and tools for immune regulation. As non-viral carriers, they represent a highly promising alternative to traditional vectors in the CGT field.
OranssiBio Advantages
- 01
GMP-ready exosome production system supporting preclinical, IND, and clinical supply - 02
Integrated analytics platform for full characterization, potency testing, and stability studies - 03
Scalable manufacturing from various cell sources (e.g., HEK293, iPSC, MSC) - 04
200L serum-free suspension system in single-use bioreactors
Service Highlights
Cell source options: human/animal-derived, stem cell-based, and custom
Purification process development: density gradient centrifugation, TFF, SEC
Comprehensive characterization: size, purity, EM imaging, protein/miRNA content
Functionalization: mRNA/siRNA loading, surface modification
Complete analytical and documentation support for preclinical and clinical use
Key Specifications
| Technical Specifications | Technical Parameters |
|---|---|
| Cell sources | HEK293, iPSC, MSC, etc. |
| Purification | ultracentrifugation, TFF, SEC |
| Concentration | >10¹¹ particles/ml |
| Characterization | NTA particle size, EM imaging, CD9/CD63/CD81 markers, RNA content |
