Lenti Virus (LV) is a powerful tool used in the field of gene therapy and gene editing. It can deliver large therapeutic payloads (up to 10kb) into target cells, either dividing or non-dividing ones, making it particularly useful for delivering genetic material into a wide range of cell types, including difficult-to-transfect or non-dividing cells.

At OranssiBio, we provide LV with the following features:

  • US/EU compliant facility with GMP and other quality requirements;
  • Fully integrated services covering process development, analytical method development, GMP manufacturing, quality control and stability testing, as well as CMC regulatory support;

  • Scalable and high productive serum-free suspension process with single use bioreactors that deliver a max batch scale at 200L; suitable for both VSVG and Baboon lentiviral vector pseudo types, with productivities up to mid 1011 TU/L;

  • Automated and fully closed purification process and fill/finish, ensuring safety and reliability;
  • A full suite of analytical methods for in-process control and finish product release, ensuring highest quality and safety of your product;
  • Streamlined operation where pre-qualified raw materials and consumables are in-stock, and pre-qualified equipment are available, allowing a rapid start of customers’ program(s).

An Illustrated Flowchart for LV

  • US/EU compliant facility with GMP and other quality requirements;
  • Fully integrated services covering process development, analytical method development, GMP manufacturing, quality control and stability testing, as well as CMC regulatory support;

  • Scalable and high productive serum-free suspension process with single use bioreactors that deliver a max batch scale at 200L; suitable for both VSVG and Baboon lentiviral vector pseudo types, with productivities up to mid 1011 TU/L;

  • Automated and fully closed purification process and fill/finish, ensuring safety and reliability;
  • A full suite of analytical methods for in-process control and finish product release, ensuring highest quality and safety of your product;
  • Streamlined operation where pre-qualified raw materials and consumables are in-stock, and pre-qualified equipment are available, allowing a rapid start of customers’ program(s).